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Naloxone pharmacology — DIPIMC MCQ

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ModeratePharmacology (Pre-Hospital)Naloxone pharmacologyDIPIMCDipIMC

An opioid overdose has been reversed with naloxone. The patient improves, but you plan a period of ongoing observation, and you are asked why.

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Naloxone has a short duration of action, so re-sedation can occur as it wears off while the opioid persists.

Naloxone has a shorter duration of action than many opioids, so a patient can re-sedate as it wears off while the opioid effect continues, which is why observation and repeat dosing or an infusion may be needed. It is given parenterally rather than orally for emergency reversal. Recognising this risk prevents premature discharge.

Reference: JRCALC Clinical Guidelines