Traumatic brain injury (physiology) — DIPIMC MCQ
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Correct answer: B — Adjust ventilation to normocapnia and maintain the systolic pressure above 110 mmHg.
Secondary brain injury is driven by hypoxia, hypotension and inappropriate carbon dioxide levels, so ventilation targets normocapnia of around 4.5 to 5.0 kPa and the systolic pressure is kept above roughly 110 mmHg in isolated head injury. Routine hyperventilation causes cerebral vasoconstriction and ischaemia. Permissive hypotension is contraindicated when significant brain injury is present.
Reference: NICE NG232 (Head injury)