Anaphylaxis — DIPIMC MCQ
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Correct answer: E — Intramuscular adrenaline 500 micrograms (0.5 mL of 1:1000) into the anterolateral thigh
Explanation lettering: C = shown as A · E = shown as B · D = shown as C · B = shown as D · A = shown as E
First-line treatment of anaphylaxis in an adult is intramuscular adrenaline 500 micrograms into the anterolateral thigh, repeated after five minutes if there is no improvement. Intravenous adrenaline 1 mg (B) is the cardiac arrest dose and is dangerous in a patient with a circulation. Steroids (D) are no longer routinely recommended in the 2025 guidance and are not first-line. The single most important drug in anaphylaxis is intramuscular adrenaline, given promptly.
Reference: Resuscitation Council UK 2025 (anaphylaxis)