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Graves disease — RACP Paediatrics MCQ

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ModerateEndocrinology and growthGraves diseaseRACP Paediatrics

A 15-year-old has weight loss, tremor, palpitations and declining school concentration. Examination shows a diffuse goitre and tachycardia; TSH is suppressed, free T4 is elevated and TSH receptor antibodies are positive. What is the most appropriate management?

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Correct answer: CCarbimazole with beta-blocker symptom control and endocrine follow-up

This is Graves disease; antithyroid therapy such as carbimazole with beta-blocker for symptoms is typical initial treatment under endocrine supervision. Levothyroxine would worsen thyrotoxicosis. The pearl is that school and behavioural changes may be prominent in adolescent hyperthyroidism.

Reference: Therapeutic Guidelines (eTG): Endocrinology; AMH Children's Dosing Companion