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Diabetic ketoacidosis — RACP Adult Medicine MCQ

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HardEndocrinology and diabetesDiabetic ketoacidosisRACP Adult Medicine

A 22-year-old woman with type 1 diabetes presents with vomiting and abdominal pain. Glucose is 29 mmol/L, ketones are 5.8 mmol/L, pH is 7.12 and potassium is 3.2 mmol/L. She is tachycardic and clinically dehydrated. What is the most appropriate management?

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Correct answer: DBegin intravenous fluids and potassium replacement before fixed-rate insulin infusion

DKA requires fluids, electrolyte correction and insulin, but hypokalaemia must be corrected before insulin because insulin will further lower potassium. Subcutaneous outpatient treatment is unsafe in severe acidosis. Routine bicarbonate is not indicated, and delaying fluids worsens shock and ketosis.

Reference: Australian Diabetes Society DKA guidelines; AMH