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Guillain-Barré syndrome — RACP Adult Medicine MCQ

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ModerateNeurologyGuillain-Barré syndromeRACP Adult Medicine

A 39-year-old man develops ascending weakness 10 days after gastroenteritis. Reflexes are absent, sensation is mildly reduced and forced vital capacity is falling. CSF shows raised protein with few cells. What is the most appropriate management?

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Correct answer: D — Admit for respiratory monitoring and give intravenous immunoglobulin or plasma exchange

Progressive Guillain-Barré syndrome requires inpatient monitoring for respiratory and autonomic failure and disease-modifying therapy with IVIG or plasma exchange. Corticosteroid monotherapy is not effective. Outpatient review, pyridostigmine or delayed tests do not address the immediate risk.

Reference: Therapeutic Guidelines (eTG); AMH