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Cancer-associated venous thromboembolism — RACP Adult Medicine MCQ

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ModerateHaematologyCancer-associated venous thromboembolismRACP Adult Medicine

A 63-year-old woman receiving chemotherapy for pancreatic cancer develops proximal DVT. Platelets are 145 x10^9/L, eGFR is 68 mL/min/1.73 m2 and there is no active bleeding. What is the most important prognostic factor?

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Correct answer: D — Active cancer type and ongoing systemic therapy

Cancer-associated thrombosis prognosis is driven by active malignancy, tumour type, treatment and bleeding risk. Pancreatic cancer and chemotherapy confer high recurrence risk and influence anticoagulant choice. Neurological signs, remote surgery, one platelet value and bruising absence do not capture the main prognosis.

Reference: Thrombosis and Haemostasis Society of Australia and New Zealand guidance; AMH