A 33-year-old woman with Crohn disease is due to start infliximab. She has no history of varicella infection and serology shows she is non-immune.

Question

A 33-year-old woman with Crohn disease is due to start infliximab. She has no history of varicella infection and serology shows she is non-immune. She is not pregnant and has no current immunosuppression. What is the most appropriate management?

Accepted Answer

Give varicella vaccination before biologic therapy and delay immunosuppression for the recommended interval

Answer

Avoid vaccination because adults cannot receive varicella vaccine

Answer

Start infliximab today and give live varicella vaccine next week

Answer

Give antibiotics instead of vaccination

Answer

Give live vaccine during neutropenic sepsis

Live vaccines before biologic therapy — RACP Adult Medicine MCQ

A 33-year-old woman with Crohn disease is due to start infliximab. She has no history of varicella infection and serology shows she is non-immune. She is not pregnant and has no current immunosuppression. What is the most appropriate management?