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Asymptomatic bacteriuria in pregnancy — USMLE Step 3 MCQ

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HardOB/GYNAsymptomatic bacteriuria in pregnancyUSMLE Step 3

A 29-year-old pregnant patient at 12 weeks' gestation is found to have asymptomatic bacteriuria with urine culture growing 100,000 CFU/mL E coli. She has no dysuria, fever, or flank pain. She has no medication allergies. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DTreat with a pregnancy-compatible antibiotic and confirm clearance

Asymptomatic bacteriuria in pregnancy should be treated because it increases the risk of pyelonephritis and adverse pregnancy outcomes. A test of cure is often performed after therapy.

Reference: ACOG urinary tract infections in pregnancy guidance