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Proteinuric chronic kidney disease hypertension — USMLE Step 3 MCQ

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HardInternal Medicine (chronic management)Proteinuric chronic kidney disease hypertensionUSMLE Step 3

A 64-year-old man with chronic kidney disease has albumin-to-creatinine ratio 780 mg/g and estimated GFR 32 mL/min/1.73 m2. Blood pressure averages 152/86 mm Hg despite amlodipine. Potassium is 4.6 mEq/L. He has no renal artery stenosis. Which of the following is the most appropriate at this time?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EStart an ACE inhibitor or ARB and monitor creatinine and potassium

ACE inhibitors or ARBs reduce albuminuria and slow CKD progression in proteinuric kidney disease, with monitoring for creatinine rise and hyperkalemia.

Reference: KDIGO chronic kidney disease blood pressure guidance