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Pheochromocytoma — USMLE Step 3 MCQ

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ModerateAmbulatory Medicine / Primary CarePheochromocytomaUSMLE Step 3

A 41-year-old woman has episodic palpitations, headache, and sweating. Blood pressure in clinic is 168/96 mm Hg, but prior readings were normal. Her father had medullary thyroid cancer. Plasma free metanephrines are elevated. Which of the following is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DObtain adrenal imaging after biochemical confirmation

Biochemically confirmed pheochromocytoma should be localized with imaging. If treatment is planned, alpha blockade precedes beta blockade to avoid unopposed alpha-adrenergic stimulation.

Reference: Endocrine Society pheochromocytoma guidance