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Hepatitis C after cure with cirrhosis — USMLE Step 3 MCQ

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HardInternal Medicine (chronic management)Hepatitis C after cure with cirrhosisUSMLE Step 3

A 58-year-old man with chronic hepatitis C completed direct-acting antiviral therapy 6 months ago. HCV RNA is undetectable. Before treatment, elastography showed cirrhosis. He does not drink alcohol and has normal bilirubin and INR. Which of the following would you recommend at the follow-up visit?

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Correct answer: AContinue ultrasound surveillance for hepatocellular carcinoma every 6 months

Sustained virologic response reduces but does not eliminate hepatocellular carcinoma risk in patients with cirrhosis. Semiannual ultrasound-based surveillance should continue.

Reference: AASLD hepatitis C and hepatocellular carcinoma guidance