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Hyperfunctioning thyroid nodule — USMLE Step 3 MCQ

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EasyAmbulatory Medicine / Primary CareHyperfunctioning thyroid noduleUSMLE Step 3

A 46-year-old woman has a 2-cm thyroid nodule found incidentally on carotid ultrasound. She has no compressive symptoms. TSH is 0.08 mIU/L. There is no cervical lymphadenopathy. Which of the following is the most appropriate next step in management?

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Correct answer: D — Radionuclide thyroid uptake scan

A thyroid nodule with suppressed TSH should be evaluated with radionuclide scanning to identify a hyperfunctioning nodule. Functioning nodules have a low malignancy risk and are not initially biopsied.

Reference: American Thyroid Association thyroid nodule guidance