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Disseminated intravascular coagulation from sepsis — RCPSC IM MCQ

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HardHematologyDisseminated intravascular coagulation from sepsisRCPSC IM

A patient with postpartum hemorrhage continues bleeding after uterotonic treatment and source-control measures are underway. Fibrinogen is 0.8 g/L and viscoelastic testing confirms severe fibrinogen deficit. What replacement should be prioritized?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EGive fibrinogen concentrate or cryoprecipitate within the major-obstetric-hemorrhage protocol

The best answer is “Give fibrinogen concentrate or cryoprecipitate within the major-obstetric-hemorrhage protocol”. Fibrinogen falls early in major obstetric hemorrhage, and a level of 0.8 g/L requires urgent targeted replacement while bleeding control and balanced resuscitation continue. Platelets or vitamin K do not replace fibrinogen, and waiting for hemoglobin ignores active coagulopathy.

Reference: Society of Obstetricians and Gynaecologists of Canada, postpartum hemorrhage guideline: https://sogc.org/common/Uploaded%20files/ACSC/ACSC2024/gui431CPG2207E.pdf