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Primary membranous nephropathy — RCPSC IM MCQ

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HardNephrologyPrimary membranous nephropathyRCPSC IM

A 58-year-old man has edema and frothy urine. Urine protein-creatinine ratio is 780 mg/mmol, albumin is 21 g/L, creatinine is 92 micromol/L and complement levels are normal. Anti-PLA2R antibody is positive. Hepatitis B, hepatitis C and malignancy screening are negative. What is the most likely diagnosis?

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Correct answer: C — Primary membranous nephropathy

Nephrotic syndrome with positive anti-PLA2R and no secondary cause is highly suggestive of primary membranous nephropathy.

Reference: KDIGO glomerular disease guideline