A 48-year-old man has fatigue, bruising and recurrent mouth ulcers. Hemoglobin is 68 g/L, neutrophils are 0.4 x 10^9/L and platelets are 18 x 10^9/L.

Question

A 48-year-old man has fatigue, bruising and recurrent mouth ulcers. Hemoglobin is 68 g/L, neutrophils are 0.4 x 10^9/L and platelets are 18 x 10^9/L. Reticulocytes are low. Bone marrow biopsy is markedly hypocellular with no dysplasia, fibrosis or malignant infiltrate. What is the most likely diagnosis?

Accepted Answer

Aplastic anemia

Answer

Acute promyelocytic leukemia

Answer

Myelodysplastic syndrome with ring sideroblasts

Answer

Warm autoimmune hemolytic anemia

Answer

Essential thrombocythemia

Aplastic anemia — RCPSC IM MCQ