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Type 4 renal tubular acidosis — RCPSC IM MCQ

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HardNephrologyType 4 renal tubular acidosisRCPSC IM

A 61-year-old with diabetic kidney disease takes candesartan and recently began trimethoprim-sulfamethoxazole. Potassium is 5.8 mmol/L, bicarbonate 17 mmol/L, chloride 113 mmol/L, the anion gap is normal and urine pH is 5.2. Which acid-base disorder is most likely?

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Correct answer: DType 4 renal tubular acidosis

The best answer is “Type 4 renal tubular acidosis”. Diabetic kidney disease and drugs that reduce aldosterone signaling or distal potassium secretion produce hyperkalemic normal-anion-gap acidosis typical of type 4 RTA. Distal and proximal RTA are usually hypokalemic, while lactate and ethylene glycol produce high-anion-gap acidosis.

Reference: Current review of type 4 renal tubular acidosis in diabetes. https://pmc.ncbi.nlm.nih.gov/articles/PMC12289468/