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Latent tuberculosis before biologic therapy — RACP Written MCQ

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HardEthics, Aboriginal health, public healthLatent tuberculosis before biologic therapyRACP Written

A 36-year-old man recently arrived from Papua New Guinea has a positive interferon-gamma release assay during employment screening. He has no symptoms, normal chest X-ray and negative sputum testing. He is due to start anti-TNF therapy for Crohn disease. What is the most appropriate management?

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Correct answer: E — Treat latent tuberculosis before anti-TNF therapy where possible

Latent tuberculosis should be treated before immunosuppression with anti-TNF therapy where feasible because reactivation risk is increased.

Reference: Therapeutic Guidelines: Antibiotic; Australian infectious diseases practice principles