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Opioid toxicity — RACP Written MCQ

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ModerateClinical PharmacologyOpioid toxicityRACP Written

A 47-year-old man is found drowsy with pinpoint pupils and respiratory rate 6/min after taking oxycodone with alcohol. Oxygen saturation is 82% and capnography shows hypoventilation. What is the most important next step?

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Correct answer: D — Naloxone titrated with airway and ventilatory support

Opioid toxicity with respiratory depression requires airway support and titrated naloxone to restore ventilation while avoiding abrupt severe withdrawal.

Reference: AMH; Therapeutic Guidelines: Toxicology and drug-interaction principles