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Clozapine agranulocytosis — RACP Written MCQ

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ModerateClinical PharmacologyClozapine agranulocytosisRACP Written

A 26-year-old man taking clozapine presents with fever and sore throat 6 weeks after initiation. Neutrophils are 0.3 x 10^9/L. What is the most important next step?

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Correct answer: D — Stop clozapine and urgently manage agranulocytosis/sepsis risk

Clozapine can cause severe neutropenia or agranulocytosis, particularly early in treatment; it should be stopped and infection risk managed urgently.

Reference: AMH; Therapeutic Guidelines: Toxicology and drug-interaction principles