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Neuroleptic malignant syndrome — RACP Written MCQ

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ModerateClinical PharmacologyNeuroleptic malignant syndromeRACP Written

A 43-year-old man on haloperidol presents with fever, rigidity and confusion. CK is 9,800 U/L, white cell count is elevated and reflexes are normal. Symptoms evolved over 2 days. What is the most likely diagnosis?

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Correct answer: A — Neuroleptic malignant syndrome

Dopamine antagonist exposure with rigidity, hyperthermia, raised CK and gradual evolution over days favours neuroleptic malignant syndrome.

Reference: AMH; Therapeutic Guidelines: Toxicology and drug-interaction principles