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Serotonin syndrome — RACP Written MCQ

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EasyClinical PharmacologySerotonin syndromeRACP Written

A 28-year-old woman taking sertraline is given tramadol for back pain. She develops agitation, sweating, diarrhoea, hyperreflexia and inducible ankle clonus. Temperature is 38.7 C. What is the most likely diagnosis?

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Correct answer: E — Serotonin syndrome

Serotonergic drug combination with clonus, hyperreflexia, agitation and autonomic features is serotonin syndrome.

Reference: AMH; Therapeutic Guidelines: Toxicology and drug-interaction principles