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Chronic lymphocytic leukaemia — RACP Written MCQ

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EasyHaematologyChronic lymphocytic leukaemiaRACP Written

A 72-year-old woman has asymptomatic lymphocytosis found on routine blood tests. Lymphocytes are 18 x 10^9/L. Blood film shows smudge cells and flow cytometry confirms a clonal CD5-positive B-cell population. Haemoglobin and platelets are normal. What is the most appropriate management?

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Correct answer: D — Observation with periodic monitoring

Early asymptomatic chronic lymphocytic leukaemia without cytopenias or bulky disease is usually monitored rather than treated immediately.

Reference: Australian blood and haematology guideline principles; Therapeutic Guidelines