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Membranous nephropathy — RACP Written MCQ

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ModerateNephrologyMembranous nephropathyRACP Written

A 64-year-old man has oedema and frothy urine. Albumin is 22 g/L, urine protein:creatinine ratio is 650 mg/mmol and PLA2R antibody is positive. He has no diabetes and renal ultrasound is normal. What is the most likely diagnosis?

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Correct answer: B — Membranous nephropathy

Nephrotic syndrome with PLA2R antibody positivity in an older adult strongly suggests primary membranous nephropathy.

Reference: Therapeutic Guidelines: Kidney and Urinary; Kidney Health Australia principles