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Granulomatosis with polyangiitis — RACP Written MCQ

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HardRheumatologyGranulomatosis with polyangiitisRACP Written

A 54-year-old man has sinusitis, haemoptysis and rapidly rising creatinine. Urine microscopy shows dysmorphic red cells and casts. CT chest shows multiple cavitating nodules and PR3-ANCA is positive. What is the most likely diagnosis?

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Correct answer: B — Granulomatosis with polyangiitis

Upper airway disease, cavitating lung nodules, glomerulonephritis and PR3-ANCA positivity are typical of granulomatosis with polyangiitis.

Reference: Therapeutic Guidelines: Rheumatology; Australian rheumatology practice principles