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Lupus nephritis — RACP Written MCQ

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HardRheumatologyLupus nephritisRACP Written

A 26-year-old woman has malar rash, arthritis and foamy urine. Creatinine is 145 micromol/L, urine protein:creatinine ratio is 180 mg/mmol and urine microscopy shows red cell casts. Complement C3 is low and anti-dsDNA is high. What is the most appropriate investigation?

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Correct answer: ARenal biopsy

Active urinary sediment and proteinuria in SLE suggest lupus nephritis; renal biopsy guides classification and immunosuppressive treatment.

Reference: Therapeutic Guidelines: Rheumatology; Australian rheumatology practice principles