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Motor neurone disease — RACP Written MCQ

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HardNeurologyMotor neurone diseaseRACP Written

A 58-year-old man has progressive asymmetric hand wasting, fasciculations and spasticity in the legs. Sensation is normal and MRI spine does not show cord compression. EMG shows active denervation in multiple regions. What is the most likely diagnosis?

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Correct answer: C — Motor neurone disease

Combined upper and lower motor neurone signs, preserved sensation and widespread denervation are typical of motor neurone disease.

Reference: Australian stroke and neurology guideline principles; Therapeutic Guidelines