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Neuromyelitis optica spectrum disorder — RACP Written MCQ

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HardNeurologyNeuromyelitis optica spectrum disorderRACP Written

A 45-year-old woman has longitudinally extensive transverse myelitis from C2 to T4 and severe optic neuritis. Brain MRI is non-specific. Serum aquaporin-4 IgG is positive. What is the most likely diagnosis?

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Correct answer: D — Neuromyelitis optica spectrum disorder

Longitudinally extensive myelitis plus optic neuritis and aquaporin-4 IgG positivity indicates neuromyelitis optica spectrum disorder.

Reference: Australian stroke and neurology guideline principles; Therapeutic Guidelines