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Autoimmune hepatitis — RACP Written MCQ

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HardGastroenterology/HepatologyAutoimmune hepatitisRACP Written

A 37-year-old woman has jaundice, fatigue and amenorrhoea. ALT is 780 U/L, IgG is elevated and ANA and smooth muscle antibody are positive. Viral hepatitis serology is negative. Liver biopsy shows interface hepatitis with plasma cells. What is the most likely diagnosis?

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Correct answer: B — Autoimmune hepatitis

Marked hepatocellular injury, raised IgG, autoantibodies and plasma cell-rich interface hepatitis are typical of autoimmune hepatitis.

Reference: Therapeutic Guidelines: Gastrointestinal; Gastroenterological Society of Australia guidance