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Case-control study design — MRCPCH TAS MCQ

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ModerateStatistics and evidence-based medicineCase-control study designMRCPCH TAS

A team identifies children with leukaemia and matched children without leukaemia, then reviews previous CT exposure. Which study design is most likely?

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Correct answer: ACase-control study

A case-control study starts with outcome status and retrospectively compares prior exposure. A prospective cohort would recruit by exposure status and follow children forward to see who develops leukaemia. The pearl is that case-control studies are efficient for rare outcomes.

Reference: RCPCH TAS specimen paper; CEBM study designs; The Science of Paediatrics MRCPCH Mastercourse