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RSV fusion protein — MRCPCH TAS MCQ

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ModerateMicrobiologyRSV fusion proteinMRCPCH TAS

A 2-month-old has bronchiolitis during winter. Nasopharyngeal PCR confirms respiratory syncytial virus. The virus forms multinucleated cells in airway epithelium. Which viral protein is most responsible?

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Correct answer: C — Fusion protein

RSV fusion protein mediates cell-to-cell fusion and syncytium formation. Neuraminidase is an influenza surface enzyme and not the key RSV protein. The pearl is that RSV bronchiolitis reflects both viral cytopathic effects and host inflammatory response in small airways.

Reference: Nelson Textbook of Pediatrics; RCPCH Theory examination syllabi; Lissauer's Illustrated Textbook of Paediatrics