Double-blind randomised controlled trial — MRCPCH TAS MCQ

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EasyStatistics and evidence-based medicineDouble-blind randomised controlled trialMRCPCH TAS

A new inhaled treatment for preschool wheeze is compared with placebo. Children are randomly allocated and neither families nor assessors know group allocation. What study design is most likely?

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Correct answer: D — Double-blind randomised controlled trial

Random allocation with blinding of participants and assessors defines a double-blind randomised controlled trial. A case-control study selects participants by outcome and looks back for exposures. The pearl is that randomisation reduces confounding and blinding reduces measurement and performance bias.

Reference: RCPCH TAS specimen paper; CEBM study designs; The Science of Paediatrics MRCPCH Mastercourse