skip to main content

Brown fat thermogenesis — MRCPCH TAS MCQ

Instant feedback + full explanation. One question, done properly.

EasyPhysiologyBrown fat thermogenesisMRCPCH TAS

A term newborn exposed to a cool delivery room maintains temperature without shivering. Brown adipose tissue metabolism increases. What is the most likely mechanism?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Uncoupling protein-mediated heat generation

Neonates use non-shivering thermogenesis in brown fat through uncoupling protein, generating heat rather than ATP. Shivering is less effective in newborns and is not the main early mechanism. The pearl is that cold stress can increase oxygen and glucose consumption in neonates.

Reference: Rennie and Robertson Textbook of Neonatology; Ganong's Review of Medical Physiology; RCPCH Theory examination syllabi