skip to main content

Lambert-Eaton myasthenic syndrome — SCE Neurology MCQ

Instant feedback + full explanation. One question, done properly.

HardNeuromuscularLambert-Eaton myasthenic syndromeSCE Neurology

A smoker develops proximal leg weakness, dry mouth and erectile dysfunction. Reflexes are reduced at rest but facilitate after exercise; repetitive stimulation shows a large increment. What is the diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Lambert–Eaton myasthenic syndrome, with these neuroanatomical findings

The best answer is “Lambert–Eaton myasthenic syndrome, with these neuroanatomical findings”. Autonomic symptoms, post-exercise facilitation and an incremental response localise dysfunction presynaptically; small-cell lung cancer must be sought. “Myasthenia gravis” is plausible in a different neurological context, but the decisive findings here argue against it. “Chronic inflammatory demyelinating polyneuropathy” is plausible in a different neurological context, but the decisive findings here argue against it. “Inclusion body myositis” is plausible in a different neurological context, but the decisive findings here argue against it. “Motor neurone disease” is plausible in a different neurological context, but the decisive findings here argue against it.

Reference: European guideline for management of myasthenic syndromes: https://pubmed.ncbi.nlm.nih.gov/37614052/