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Efgartigimod in generalised myasthenia — SCE Neurology MCQ

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HardNeuroimmunologyEfgartigimod in generalised myastheniaSCE Neurology

A patient with motor neurone disease has a weak cough and recurrent mucus retention. Manually assisted cough and breath stacking no longer produce adequate peak cough flow. What should be added next?

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Correct answer: CIntroduce mechanical cough assistance with respiratory-physiotherapy support now

NICE uses a stepwise cough-augmentation pathway: manual assisted cough and breath stacking, followed by assisted breath stacking, then mechanical cough assistance when simpler measures are ineffective or during infection. Nebulised saline may thin secretions but does not generate cough flow, antibiotics treat infection, CPAP does not replace cough assistance, and routine bronchoscopy is invasive rescue rather than maintenance.

Reference: NICE NG42 motor neurone disease: recommendations (Current NICE recommendations, accessed July 2026): https://www.nice.org.uk/guidance/ng42/chapter/Recommendations