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Diabetic CKD — ESENeph MCQ

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ModerateChronic Kidney DiseaseDiabetic CKDESENeph

A 61-year-old woman with type 2 diabetes has CKD despite maximally tolerated losartan. eGFR is 38 mL/min/1.73 m², urine ACR is 78 mg/mmol and potassium is 4.8 mmol/L. HbA1c is 58 mmol/mol and there is no history of recurrent genital infection. What is the most appropriate management?

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Correct answer: CAdd an SGLT2 inhibitor with sick-day advice

SGLT2 inhibitors reduce CKD progression and cardiovascular events in albuminuric diabetic CKD when eGFR is within licensed and guideline-supported thresholds. Stopping tolerated RAAS blockade would remove an established renal-protective therapy. Steroids and erythropoietin do not treat diabetic albuminuric kidney disease. The pearl is that early eGFR dip after SGLT2 initiation is expected, but a larger or symptomatic decline should prompt review.

Reference: NICE NG203; NICE TA775/TA942; KDIGO 2024 CKD Guideline