Post-transplant lymphoproliferative disorder — ESENeph MCQ

Correct answer: E — Post-transplant lymphoproliferative disorder

The best answer is “Post-transplant lymphoproliferative disorder”. Donor-positive/recipient-negative EBV mismatch and T-cell depletion are strong risk factors. Tissue diagnosis is required, followed by coordinated reduction of immunosuppression and lymphoma-directed treatment. “Acute T-cell-mediated rejection” is less appropriate because rejection primarily causes graft dysfunction rather than systemic nodal disease “BK polyomavirus nephropathy” is less appropriate because BK disease predominantly affects the graft and urinary tract “Recurrent focal segmental glomerulosclerosis” is less appropriate because this presents with proteinuria rather than fever and lymphadenopathy “Calciphylaxis” is less appropriate because this produces painful skin and soft-tissue lesions

Reference: UK Kidney Association post-operative care guideline for kidney-transplant recipients: https://www.ukkidney.org/health-professionals/guidelines/post-operative-care-kidney-transplant-recipient