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Metabolic acidosis in CKD — ESENeph MCQ

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HardChronic Kidney DiseaseMetabolic acidosis in CKDESENeph

A 66-year-old woman with CKD G4 has fatigue and worsening breathlessness. eGFR is 24 mL/min/1.73 m², bicarbonate 16 mmol/L and chloride 113 mmol/L. Venous pH is 7.30 and potassium is 5.1 mmol/L; she is euvolaemic. What is the most appropriate management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DStart oral sodium bicarbonate and monitor volume status

CKD-related normal anion gap metabolic acidosis can be treated with oral bicarbonate when persistent and clinically appropriate, while monitoring blood pressure and fluid status. Acetazolamide would worsen metabolic acidosis. Dialysis is not triggered by bicarbonate alone if the patient is stable and manageable medically. The pearl is that correcting metabolic acidosis may slow CKD progression and improve muscle and bone health.

Reference: NICE NG203; KDIGO 2024 CKD Guideline