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Mucous membrane pemphigoid — NDEB AFK MCQ

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HardOral PathologyMucous membrane pemphigoidNDEB AFK

A 67-year-old woman has desquamative gingivitis and tense blisters that rupture slowly. Ocular irritation is also reported. Biopsy is planned. What is the most appropriate investigation?

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Correct answer: B — Perilesional biopsy for direct immunofluorescence

Suspected mucous membrane pemphigoid requires biopsy including perilesional tissue for direct immunofluorescence. A swab culture cannot diagnose autoimmune subepithelial blistering disease. The pearl is that ocular involvement can scar and should prompt medical or ophthalmology coordination.

Reference: Canadian oral medicine reference texts; NDEB KSAs 2024