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Central giant cell lesion versus hyperparathyroidism — NDEB AFK MCQ

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HardOral PathologyCentral giant cell lesion versus hyperparathyroidismNDEB AFK

A 34-year-old has multiple multilocular radiolucencies in the mandible. Teeth are vital, biopsy shows multinucleated giant cells, and serum calcium is elevated. What is the most appropriate investigation?

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Correct answer: A — Parathyroid hormone and endocrine assessment

Multiple giant-cell jaw lesions with hypercalcaemia require evaluation for hyperparathyroidism, including parathyroid hormone testing. Endodontic treatment is not indicated when involved teeth are vital and the pathology is systemic/metabolic. The pearl is that brown tumours can mimic central giant cell lesions histologically, so biochemical correlation is essential.

Reference: Canadian oral pathology reference texts; NDEB released item style