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Salivary IgA deficiency pattern — NDEB AFK MCQ

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ModerateBiomedical SciencesSalivary IgA deficiency patternNDEB AFK

A dental student notes that a patient with reduced salivary protection develops frequent mucosal infections and caries despite reasonable brushing. The clinician explains that the dominant immunoglobulin in saliva is reduced. What is the most likely cause/mechanism?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Reduced secretory IgA-mediated mucosal defence

Secretory IgA is the major salivary immunoglobulin and contributes to mucosal immune defence and microbial control. IgE is not the dominant protective immunoglobulin in saliva. The pearl is that saliva protects through buffering, remineralisation, lubrication, antimicrobial proteins, and immune factors.

Reference: Oral biology reference texts; NDEB released item style