skip to main content

Premature ovarian insufficiency — DRCOG MCQ

Instant feedback + full explanation. One question, done properly.

HardGynaecologyPremature ovarian insufficiencyDRCOG

A 36-year-old woman has 7 months of amenorrhoea, hot flushes and vaginal dryness. Pregnancy test is negative. Two FSH measurements taken 6 weeks apart are raised. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Premature ovarian insufficiency

Amenorrhoea with vasomotor symptoms and repeatedly raised FSH before age 40 is consistent with premature ovarian insufficiency. PCOS usually has hyperandrogenic features and does not cause low-oestrogen symptoms in this way. Hyperprolactinaemia should be considered in amenorrhoea but would not cause raised FSH. The pearl is that POI has bone and cardiovascular implications, so hormonal replacement is usually advised unless contraindicated.

Reference: NICE NG23