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Tricyclic antidepressant poisoning — ACEM Fellowship MCQ

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ModerateToxicologyTricyclic antidepressant poisoningACEM Fellowship

A 44-year-old woman presents to a Perth ED, triage category 1, after amitriptyline overdose. GCS 9, BP 86/52. ECG shows QRS 150 ms and terminal R wave in aVR. She has a brief generalised seizure. What is the most appropriate management?

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Correct answer: BIV sodium bicarbonate

Wide QRS, hypotension and seizure after amitriptyline are sodium-channel blockade; sodium bicarbonate is first-line.

Reference: eTG toxicology; Poisons Information Centre TCA guidance