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Cancer-associated venous thromboembolism — ABIM Board MCQ

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HardHematology/OncologyCancer-associated venous thromboembolismABIM Board

A 70-year-old woman with metastatic pancreatic cancer develops symptomatic proximal DVT. Platelets are 160000/mm3, creatinine clearance is 55 mL/min, and she has no active luminal GI bleeding. Which of the following is the most appropriate management?

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Correct answer: A — Therapeutic anticoagulation with a DOAC or low-molecular-weight heparin after bleeding-risk assessment

Cancer-associated thrombosis is treated with therapeutic anticoagulation. DOACs or LMWH are options, but GI cancer bleeding risk, drug interactions, renal function, thrombocytopenia, and patient preference guide selection.

Reference: ASH VTE in Cancer Guideline; NCCN Cancer-Associated VTE Guidance