Asymptomatic chronic lymphocytic leukemia — ABIM Board MCQ
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Correct answer: A — Begin observation with periodic monitoring
Asymptomatic early-stage CLL is managed with observation until treatment indications develop, such as symptomatic disease, threatened organ function, progressive marrow failure, bulky nodes, or autoimmune cytopenias not controlled with standard therapy.
Reference: NCCN Chronic Lymphocytic Leukemia Guidance; iwCLL Criteria