A 37-year-old woman has cough, erythema nodosum, ankle pain, and bilateral hilar lymphadenopathy. Serum calcium is 11.2 mg/dL and

Question

A 37-year-old woman has cough, erythema nodosum, ankle pain, and bilateral hilar lymphadenopathy. Serum calcium is 11.2 mg/dL and 1,25-dihydroxyvitamin D is elevated. Which of the following is the most likely cause?

Accepted Answer

Macrophage-mediated extrarenal 1-alpha hydroxylase activity

Answer

Vitamin D intoxication from excess supplement use

Answer

Parathyroid hormone-related peptide secretion

Answer

Familial hypocalciuric hypercalcemia

Answer

Osteolytic bone metastases

Sarcoidosis-associated hypercalcemia — ABIM Board MCQ

A 37-year-old woman has cough, erythema nodosum, ankle pain, and bilateral hilar lymphadenopathy. Serum calcium is 11.2 mg/dL and 1,25-dihydroxyvitamin D is elevated. Which of the following is the most likely cause?