skip to main content

Cryptococcal meningitis in AIDS — ABIM Board MCQ

Instant feedback + full explanation. One question, done properly.

HardInfectious DiseaseCryptococcal meningitis in AIDSABIM Board

A 38-year-old man with AIDS, CD4 count 32 cells/mm3, has headache, fever, and confusion. Opening pressure is 34 cm H2O. CSF shows lymphocytic pleocytosis, low glucose, and positive cryptococcal antigen. Which of the following is the most appropriate management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Induction therapy with liposomal amphotericin B plus flucytosine and serial management of intracranial pressure

Cryptococcal meningitis in AIDS requires amphotericin-based induction plus flucytosine, careful management of elevated intracranial pressure with serial lumbar punctures, and delayed ART initiation to reduce severe IRIS risk.

Reference: DHHS HIV Opportunistic Infection Guidelines; IDSA Cryptococcal Disease Guideline