A 57-year-old woman has calcium 11.5 mg/dL, PTH 118 pg/mL, eGFR 52 mL/min/1.73 m2, and 24-hour urine calcium 340 mg/day. DXA shows T-score minus 2.7

Question

A 57-year-old woman has calcium 11.5 mg/dL, PTH 118 pg/mL, eGFR 52 mL/min/1.73 m2, and 24-hour urine calcium 340 mg/day. DXA shows T-score minus 2.7 at the femoral neck. She has no kidney stones. Which of the following is the most likely diagnosis?

Accepted Answer

Primary hyperparathyroidism with skeletal involvement

Answer

Granulomatous calcitriol excess

Answer

Familial hypocalciuric hypercalcemia

Answer

Vitamin D intoxication

Answer

Malignancy-associated hypercalcemia

Primary hyperparathyroidism — ABIM Board MCQ

A 57-year-old woman has calcium 11.5 mg/dL, PTH 118 pg/mL, eGFR 52 mL/min/1.73 m2, and 24-hour urine calcium 340 mg/day. DXA shows T-score minus 2.7 at the femoral neck. She has no kidney stones. Which of the following is the most likely diagnosis?