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Obesity with metabolic comorbidity — ABIM Board MCQ

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ModerateGeneral Internal MedicineObesity with metabolic comorbidityABIM Board

A 45-year-old woman has BMI 38 kg/m2, prediabetes, obstructive sleep apnea, and unsuccessful lifestyle-only weight loss. She has no personal or family history of medullary thyroid carcinoma or MEN2 and is not pregnant. Which of the following would you recommend?

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Correct answer: AMetabolic-bariatric surgery discussion and anti-obesity pharmacotherapy options such as GLP-1 or dual incretin therapy

Adults with BMI at least 30, or at least 27 with weight-related comorbidity, are candidates for anti-obesity pharmacotherapy as adjunct to lifestyle therapy. BMI 35 or higher with comorbidities also warrants metabolic-bariatric surgery discussion.

Reference: AACE Obesity Guideline; ADA Standards of Care in Diabetes 2026