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Serotonin syndrome — ABEM Board MCQ

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HardPsychiatric emergenciesSerotonin syndromeABEM Board

A 23-year-old man presents as triage level 2 with agitation, diaphoresis, hyperreflexia, inducible clonus, and temperature 39.4°C after taking sertraline and linezolid. Pupils are dilated and bowel sounds are increased. Which of the following is the most likely diagnosis?

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Correct answer: ESerotonin syndrome

Clonus, hyperreflexia, autonomic instability, and serotonergic medication exposure distinguish serotonin syndrome from NMS and anticholinergic toxicity.

Reference: ACEP toxicology guidance; ABEM EM Model